{"id":1054,"date":"2025-09-04T15:49:25","date_gmt":"2025-09-04T12:49:25","guid":{"rendered":"https:\/\/www.lbscience.org\/en\/2025\/09\/04\/a-new-passive-vaccine-against-rsv\/"},"modified":"2025-09-20T00:44:30","modified_gmt":"2025-09-19T21:44:30","slug":"a-new-preventive-measure-against-rsv","status":"publish","type":"post","link":"https:\/\/www.lbscience.org\/en\/2025\/09\/04\/a-new-preventive-measure-against-rsv\/","title":{"rendered":"A New Preventive Measure Against RSV"},"content":{"rendered":"

Respiratory syncytial virus, or RSV for short, is an RNA virus belonging to the Paramyxoviridae family, which also includes the viruses that cause measles and mumps. Most infections occur in children under two years of age, and people can contract and fall ill with RSV more than once. The disease affects the airways and usually presents as a mild cold accompanied by cough and low-grade fever, but in preterm infants and other risk groups, such as children with congenital heart defects, it can progress to bronchitis and pneumonia and become life-threatening. Signs that the illness has become complicated include severe coughing, breathing difficulties, wheezing, and apnea. The disease most commonly appears in winter. <\/span>
\n<\/span>Because there is no specific antiviral treatment, hospitalized patients generally receive supportive care: inhalations, oxygen, fluids, and, in severe cases, mechanical ventilation.<\/span><\/p>\n

\"\"

Scanning electron micrograph of human respiratory syncytial virus (RSV) virions (colorized blue) and labeled with anti-RSV F protein\/gold antibodies (colorized yellow) shedding from the surface of human lung epithelial A549 cells | Source: NIAID<\/p><\/div>\n

As noted, the new preventive medication contains an antibody that binds to the virus and prevents it from entering its target cells in the bronchi and lungs, thereby reducing infection and disease severity. The antibodies remain effective for about six months after injection. Beyfortus does not provide active immunity like vaccines in which the virus or parts of it are injected into the body, but rather it provides passive immunity. In passive immunization, products of the immune system are taken from another source\u2014in this case, lab-produced antibodies rather than blood donations\u2014and introduced into the patient\u2019s body. The immune system is therefore not activated and does not create immunological memory against the disease, so the protection is temporary.<\/span><\/p>\n

Beyfortus has been used worldwide since 2023 in 25 countries, where it has reduced RSV-related hospitalizations by about 80%. Side effects after injection are usually mild: redness, local pain, and sometimes a slight rash at the injection site. The new medication replaces the previous antibody product Synagis (or <\/span>palivizumab)<\/span>, whose activity lasts only about a month and therefore had to be given in five monthly doses, and was reserved only for preterm infants and other high-risk newborns. <\/span><\/p>\n

Since 2023, three active RSV vaccines have also been approved, all aiming to generate immune memory against the virus\u2019s envelope protein (F). They are intended for adults over 18 and especially for women in the third trimester of pregnancy\u2014to protect the newborn until six months of age. In practice, other than for pregnant women, most countries recommend them for adults over 60 or 75, depending on local guidelines.<\/span>
\n<\/span>The first vaccine is Pfizer\u2019s Abrysvo, which contains the F envelope protein of the virus\u2019s two main strains. The second is Moderna\u2019s mRESVIA, which contains mRNA encoding the F envelope protein. The third is GSK\u2019s Arexvy, which contains the F envelope protein along with the adjuvant <\/span>AS01E. <\/span>The first two vaccines are not currently being used in Israel. The vaccine by GSK will be deployed in Israel starting in the winter of 2025, and will be offered to people 65 and older.<\/span><\/p>\n

This is genuine good news for parents and children in Israel: effective protection against a dangerous respiratory illness from the very first months of life, promising to reduce infant suffering and ease the burden on pediatric care centers.<\/span><\/p>\n

Hebrew editing: Galia Halevy-Sade
\nEnglish editing: Elee Shimshoni<\/span><\/p>\n

\n

Sources<\/b><\/p>\n

    \n
  1. RSV antibody preparation on the U.S. CDC website<\/span><\/a><\/li>\n
  2. RSV antibody preparation on the EMA website<\/span><\/a><\/li>\n
  3. Pfizer\u2019s active vaccine<\/span><\/a><\/li>\n
  4. Moderna\u2019s active vaccine<\/span><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Respiratory syncytial virus, or RSV for short, is an RNA virus belonging to the Paramyxoviridae family, which also includes the viruses that cause measles and mumps. Most infections occur in children under two years of age, and people can contract and fall ill with RSV more than once. The disease affects the airways and usually […]<\/p>\n","protected":false},"author":9,"featured_media":1055,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine"],"acf":[],"yoast_head":"\nA New Preventive Measure Against RSV - Little, Big Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lbscience.org\/en\/2025\/09\/04\/a-new-preventive-measure-against-rsv\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A New Preventive Measure Against RSV - Little, Big Science\" \/>\n<meta property=\"og:description\" content=\"Respiratory syncytial virus, or RSV for short, is an RNA virus belonging to the Paramyxoviridae family, which also includes the viruses that cause measles and mumps. 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