{"id":307,"date":"2020-06-02T18:59:19","date_gmt":"2020-06-02T15:59:19","guid":{"rendered":"https:\/\/www.lbscience.org\/en\/2025\/06\/02\/fountain-of-youth\/"},"modified":"2025-06-07T05:46:52","modified_gmt":"2025-06-07T02:46:52","slug":"fountain-of-youth","status":"publish","type":"post","link":"https:\/\/www.lbscience.org\/en\/2020\/06\/02\/fountain-of-youth\/","title":{"rendered":"Fountain of Youth?"},"content":{"rendered":"<p style=\"text-align: left;\"><span style=\"font-weight: 400;\">Collagens are the most abundant proteins in our bodies. They are found in tissues outside the cells and constitute a central component of\u00a0 <\/span><span style=\"font-weight: 400;\">a network of proteins and sugars called the <\/span><span style=\"font-weight: 400;\">\u201cextracellular matrix\u201d. This network acts as a sort of scaffold that links cells to form a tissue and provides them with structural support. Collagens are a family of proteins with varying properties, but mostly the general term \u201ccollagen\u201d refers to Type I collagen. Collagen\u2014especially Type I\u2014has a key role in our skin, and it is the hero of this article.<\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-weight: 400;\">In the skin, collagen is found in the layer called the dermis and is organized as fibers. The thickness of these fibers and their spatial arrangement, together with other factors, determine the rigidity and elasticity of the skin. The main cells responsible for producing collagen and building the matrix are called fibroblasts, and they have a central role in wound healing. In the event of an injury, such as a scratch, fibroblasts will divide and migrate to the injury site. There they secrete collagen and other components to close the wound quickly, prevent infection, and allow the tissue to recover.<\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-weight: 400;\">During aging, the collagen in the dermis undergoes profound structural changes. Over time, collagen fibers are damaged in various ways that lead to increased stiffness of the fibers and decreased elasticity. In addition, more and more fibroblasts in the skin enter a state of cellular senescence. In this state, fibroblasts lose their ability to divide and renew themselves. Senescent fibroblasts also produce less collagen and more collagen-degrading substances. <\/span><span style=\"font-weight: 400;\">These processes reinforce one another: changes in collagen properties impair the ability of fibroblasts to adhere to and move along collagen fibers, thus lowering collagen production, further hindering fibroblast motility. Collectively, these changes give the skin traits characteristic of aged skin\u2014reduced elasticity, wrinkles, and slower wound healing [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4089350\/\"><span style=\"font-weight: 400;\">1<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6985772\/\"><span style=\"font-weight: 400;\">2<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002944010622055\"><span style=\"font-weight: 400;\">3<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0047637498001195\"><span style=\"font-weight: 400;\">4<\/span><\/a><span style=\"font-weight: 400;\">].<\/span><\/p>\n<p>Is it possible to stimulate collagen production in our skin by consuming collagen or its building blocks, thus rejuvenating the skin?<\/p>\n<p style=\"text-align: left;\">Collagen, like all other proteins, is composed of amino acids. However, collagen also contains hydroxyproline, a special amino acid found primarily in collagen. Collagen-based nutritional supplements that are marketed to us at every opportunity contain hydrolyzed collagen. This means they contain short chains of amino acids that are originally derived from collagen and thus contain hydroxyproline. At first glance, the idea seems promising: we consume collagen building blocks, they enter the bloodstream [<a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/jf062834s\">5<\/a>] and from there reach the skin\u2019s fibroblasts, which will then produce collagen. The problem is that fibroblasts cannot synthesize collagen using hydroxyproline. The cellular process for collagen production is to first create the \u201cskeleton\u201d of collagen from other amino acids, and only at a later stage convert some amino acids into hydroxyproline.<\/p>\n<p style=\"text-align: left;\"><span style=\"font-weight: 400;\">So are we merely being sold magic potions? The answer is complicated.<\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-weight: 400;\">Evidence accumulated <\/span><span style=\"font-weight: 400;\">in recent years<\/span><span style=\"font-weight: 400;\"> suggests that daily intake<\/span><span style=\"font-weight: 400;\"> of collagen supplements <\/span><span style=\"font-weight: 400;\">for 2\u20133 months has a beneficial effect on skin elasticity, moisture, and wrinkle depth [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6073484\/\"><span style=\"font-weight: 400;\">6<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.karger.com\/Article\/Abstract\/351376\"><span style=\"font-weight: 400;\">7<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4206255\/\"><span style=\"font-weight: 400;\">8<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/journals.lww.com\/aswcjournal\/Fulltext\/2020\/04000\/Effect_of_an_Oral_Nutrition_Supplement_Containing.4.aspx\"><span style=\"font-weight: 400;\">9<\/span><\/a><span style=\"font-weight: 400;\">]. It should be noted that most of these studies were conducted in collaboration with supplement manufacturers; beyond that, their main limitation is that they compared the group that received supplements with a group that took a non-protein product. <\/span><span style=\"font-weight: 400;\">It is possible that consumption of collagen building blocks produced the cosmetic results, but it is also possible that increased intake of any protein could yield similar effects. Nevertheless, a series of studies\u00a0[<\/span><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jf802785h\"><span style=\"font-weight: 400;\">10<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1346-8138.2010.00827.x\"><span style=\"font-weight: 400;\">11<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2019\/FO\/C9FO00610A#!divAbstract\"><span style=\"font-weight: 400;\">12<\/span><\/a><span style=\"font-weight: 400;\">] showed that collagen-specific building blocks affect processes that contribute to skin appearance. For example, one of the building blocks found in collagen supplements\u2014 a pair of proline and hydroxyproline\u2014which can be absorbed in the intestine to\u00a0 reach the bloodstream, induces fibroblasts to divide more rapidly and to secrete fewer collagen-degrading substances, even compared with a mixture of individual amino acids. As another example, amino acid pairs or triplets unique to hydrolyzed collagen enhance the production of collagen and other components important for extracellular matrix function and skin hydration. These studies nevertheless suggest that similar effects would arise from increased consumption of collagen from any source, since it is broken down in the intestine into its various building blocks.<\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-weight: 400;\">Although there is some evidence that collagen supplements can have cosmetic effects, it is unclear how long these effects last. To date, there is no proof that fancy (and expensive) packaged hydrolyzed collagen is superior to collagen rich meat or fish gelatin from the supermarket. It is important to consult with your family physician or a licensed dietitian before taking nutritional supplements.<\/span><\/p>\n<p>Editing: Gloria Volohonsky<\/p>\n<hr \/>\n<p><b>References:<\/b><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4089350\/\"><span style=\"font-weight: 400;\">Description of structural changes in skin collagen during aging<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6985772\/\"><span style=\"font-weight: 400;\">Effect of aging on wound healing in the skin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002944010622055\"><span style=\"font-weight: 400;\">Function of fibroblasts in aged skin and the link to reduced collagen production<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0047637498001195\"><span style=\"font-weight: 400;\">Biological mechanisms underlying collagen aging<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/jf062834s\"><span style=\"font-weight: 400;\">Study showing that peptides containing hydroxyproline are absorbed from the digestive tract into the bloodstream<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6073484\/\"><span style=\"font-weight: 400;\">Clinical study demonstrating the cosmetic effect on skin of consuming hydrolyzed collagen, Kim et al. 2018<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.karger.com\/Article\/Abstract\/351376\"><span style=\"font-weight: 400;\">Clinical study demonstrating the cosmetic effect on skin of consuming hydrolyzed collagen, Proksch et al. 2014<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4206255\/\"><span style=\"font-weight: 400;\">Clinical study demonstrating the cosmetic effect on skin of consuming hydrolyzed collagen, Borumand et al. 2014<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/journals.lww.com\/aswcjournal\/Fulltext\/2020\/04000\/Effect_of_an_Oral_Nutrition_Supplement_Containing.4.aspx\"><span style=\"font-weight: 400;\">Clinical study demonstrating the cosmetic effect on skin of consuming hydrolyzed collagen, Nomoto 2020<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jf802785h\"><span style=\"font-weight: 400;\">Study showing that peptides containing hydroxyproline stimulate fibroblast growth<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1346-8138.2010.00827.x\"><span style=\"font-weight: 400;\">Study showing that peptides containing hydroxyproline enhance fibroblast proliferation and hyaluronic acid secretion<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2019\/FO\/C9FO00610A#!divAbstract\"><span style=\"font-weight: 400;\">Study showing that collagen-derived peptides inhibit collagen degradation and promote collagen synthesis by fibroblasts<\/span><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Collagens are the most abundant proteins in our bodies. They are found in tissues outside the cells and constitute a central component of\u00a0 a network of proteins and sugars called the \u201cextracellular matrix\u201d. This network acts as a sort of scaffold that links cells to form a tissue and provides them with structural support. Collagens [&hellip;]<\/p>\n","protected":false},"author":120,"featured_media":350,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,8,9],"tags":[],"class_list":["post-307","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biology","category-medicine","category-nutrition"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fountain of Youth? - Little, Big Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lbscience.org\/en\/2020\/06\/02\/fountain-of-youth\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fountain of Youth? - Little, Big Science\" \/>\n<meta property=\"og:description\" content=\"Collagens are the most abundant proteins in our bodies. 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